Neurology Seminar

Event Details

■Title: Self-organization of polarized neocortical organoids with areal signatures upon the formation of anterior and posterior organizers
■Speaker: Momoko Watanabe, University of California Irvine

Watanabe is an up-and-coming young researcher specializing in Neocortical organoids derived from human iPS cells. She leads an independent laboratory at University of California Irvine. She will give a seminar in Kanazawa on the occasion of her temporary return to Japan. We are looking forward to your participation.

Neocortical organoids derived from human pluripotent stem cells (hPSCs) have emerged as an accessible and invaluable tool to study human neurodevelopment and disease. Neocortical organoids consistently self-organize into the laminar architecture of the human cortex dorsoventrally. However, neocortical organoids currently still lack a controlled induction in the anteroposterior axis. Here, we demonstrate the polarization of neocortical organoids with the activation of anteroposterior signaling. We observed organizer formations that in turn self-polarize into distinct areal signatures. Many neurodevelopmental disorders have specific dysregulation in different areas within the neocortex. Thus, the demonstration of the anteroposterior polarization would serve as a powerful platform to study various neurological disorders that have differential effects on neocortical areas.

■Courses for which credit is granted:
 - Doctoral Course, Division of Medicine, Graduate School of Medical Sciences
    Course Title "Up-to-date Seminar"

 - School of Medicine
    Course Title "Latest Medical Research"

■Venue: Juzen Studio, 2nd floor
   (Medical Library,Takara-machi Area of Takara-machi /Tsuruma campus, Kanazawa University)Click here for a map of the 2nd floor Juzen Studio

Contact

Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Medicine　Hiroshi Kawasaki Professor E-mail: kawasaki-labo(a)umin.ac.jp *(a) should be replaced by @.